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Target intelligence / Profile preview
Plasmalemma Vesicle-Associated Protein (PLVAP) (PLVAP)
- Target
- PLVAP
- Molecular classification
- Transmembrane protein, Type II transmembrane protein
01
Overview
PLVAP is a type II transmembrane protein that plays a crucial role in the formation of diaphragms within caveolae, fenestrae, and transendothelial channels, contributing to the regulation of vascular permeability and leukocyte trafficking. Beyond its structural function, PLVAP is implicated in pathological conditions such as diabetic retinopathy and tumor angiogenesis, where its expression is often upregulated.
- Other names
- PV-1PV1gp68FELSFenestrated Endothelial-Linked Structure ProteinPlasmalemma Vesicle Protein 1DIAR10
02
Mechanism of action
Drugs targeting PLVAP might modulate its expression to regulate vascular permeability and leukocyte trafficking, potentially offering therapeutic benefits in conditions like diabetic retinopathy and cancer.
03
Biological functions
Structural component in diaphragmsRegulation of vascular permeabilityLeukocyte traffickingPositive regulation of cellular extravasationTumor necrosis factor-mediated signaling pathway
04
Disease associations
Diabetic retinopathyDiabetic macular edemaTumor angiogenesisPolycythemia veraGlomerular injuryCancer
05
Safety considerations
There are no specific safety concerns mentioned in the search results. However, therapies targeting PLVAP would need to consider its role in maintaining vascular integrity and its involvement in inflammatory responses.
06
Biomarkers
PLVAP expression as a marker for vascular remodelingPLVAP expression as a diagnostic or prognostic biomarker in conditions like brain tumors and glomerular injury
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