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Plasmodium dihydropteroate synthase and dihydrofolate reductase (DHPS-DHFR) folate pathway (Plasmodium DHPS-DHFR)

Target: Plasmodium DHPS-DHFR

Overview

The Plasmodium DHPS-DHFR folate pathway is a vital metabolic sequence in malaria-causing parasites, such as Plasmodium falciparum}

Other names: Plasmodium folate biosynthesis pathwayP. falciparum DHPS-DHFRAntifolate target pathwayBifunctional DHFR-TS and HPPK-DHPS system

Biological functions

Nucleotide metabolismCell proliferationDNA replication

Biomarkers

pfdhfr gene mutations (e.g., S108N, N51I, C59R) [Source: PubMed PMID: 16122556]pfdhps gene mutations (e.g., A437G, K540E, I581G) [Source: PubMed PMID: 16122556]

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