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Target intelligence / Profile preview
Plasmodium falciparum Cytochrome bc1 Complex (Qi Site) (Pf bc1 (Qi site))
- Target
- Pf bc1 (Qi site)
- Molecular classification
- Enzyme, Mitochondrial respiratory complex, Cytochrome bc1 complex subunit
01
Overview
The cytochrome bc1 complex, specifically its ubiquinone-reduction (Qi) site in Plasmodium falciparum, is a critical target for antimalarial drug development. The Qi site is responsible for reducing ubiquinone, a process essential for regenerating oxidized ubiquinone required by dihydroorotate dehydrogenase (DHODH) in pyrimidine biosynthesis. Inhibition of the Qi site disrupts the electron transport chain, halts DHODH function, and leads to parasite death. Several drug classes, including pyridones and endochin-like quinolones, target the Qi site. Resistance can develop through mutations within cytochrome b. Targeting the Qi site remains a validated strategy for antimalarial drug development.
- Other names
- Cytochrome b (Qi site)Ubiquinone-reduction site of cytochrome bc1 complexComplex III Qi site
02
Mechanism of action
Inhibition of ubiquinone reduction at the Qi site, leading to disruption of electron transport chain and pyrimidine biosynthesis
03
Biological functions
Electron transferProton translocationUbiquinone reductionRegeneration of oxidized ubiquinone
04
Disease associations
InfectionMalaria
05
Safety considerations
Potential for drug resistance development through mutations in cytochrome bCross-resistance to other inhibitors targeting different sites within the complex
06
Interacting drugs
ELQ300
2 more in the full profile.
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