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Plasmodium Species (Blood Stage)
- Molecular classification
- Protozoan parasite, Enzyme, Transporter, Other
01
Overview
Plasmodium species are protozoan parasites responsible for malaria in humans. The blood stage of these parasites is clinically significant, as it is responsible for the symptoms and pathology of malaria. The most important human-infecting species include Plasmodium falciparum, P. vivax, P. ovale, and P. malariae. This stage is targeted by most antimalarial drugs.
- Other names
- Malaria parasite (blood stage)Intraerythrocytic Plasmodium
02
Mechanism of action
Inhibition of parasite enzymes, disruption of parasite metabolism, interference with hemoglobin digestion, disruption of mitochondrial function, prevention of gametocyte development
03
Biological functions
Asexual replicationNutrient uptakeHemoglobin digestionImmune evasionInvasion of red blood cells
04
Disease associations
Malaria
05
Safety considerations
Drug resistanceAdverse drug reactionsPregnancy complications
06
Interacting drugs
Chloroquine
5 more in the full profile.
07
Biomarkers
Parasite density (parasitemia)Presence of specific Plasmodium speciesDrug resistance markers
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