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Target intelligence / Profile preview
Plastoquinone (PQ) or Plastoquinone-binding sites in photosynthetic complexes (PQ)
- Target
- PQ
- Molecular classification
- Cofactor, Electron transport molecule, Quinone derivative
01
Overview
Plastoquinone is a lipophilic quinone cofactor essential to photosynthetic electron transport in plants, algae, and cyanobacteria. It functions within specialized binding sites in photosystems II and I, accepting and donating electrons while facilitating proton translocation across thylakoid membranes. At the QB site in PSII, plastoquinone accepts two electrons and two protons before being released and replaced by a fresh molecule, while the QA site maintains a tightly bound plastoquinone that transfers single electrons. Although structurally similar to ubiquinone (coenzyme Q10), plastoquinone is specific to photosynthetic organisms and does not represent a traditional pharmaceutical target for human disease treatment.
- Other names
- PlastoquinolUbiquinone analogPhotosynthetic quinone
02
Mechanism of action
N/A
03
Biological functions
Electron transfer in photosynthetic electron transport chainsProton translocation and gradient formationDouble electron and proton acceptance at QB binding sitesElectron shuttling between PSII and PSI
04
Disease associations
None established in human disease (plastoquinone is involved in plant photosynthesis, not human physiology)
05
Safety considerations
N/A
06
Interacting drugs
None (plastoquinone is a natural photosynthetic cofactor, not a drug target)
07
Biomarkers
N/A
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