Pleckstrin homology domain containing, family O member 1 (PLEKHO1)

PLEKHO1 encodes a scaffolding protein with a pleckstrin homology domain that mediates protein-protein interactions, subcellular localization, and key signaling events[1][4]. It recruits protein kinase CK2 to the plasma membrane, modulates transcription (AP-1/c-Jun), and influences apoptosis via caspase-mediated cleavage and nuclear translocation[1]. PLEKHO1 is also essential for bone formation, immune cell polarization, and the regulation of cell cycle and protein degradation. In various cancers, PLEKHO1 is dysregulated and contributes to tumorigenesis, with its roles being highly context-dependent (can be tumor suppressive or promotive depending on cancer type); genetic variants are linked to metabolic and cardiovascular risk[2][4].

Other names

CKIP-1OC120CKIP1JBPpleckstrin homology domain containing O1

Inhibition of PLEKHO1 (e.g., siRNA) leads to increased bone formation via suppression of Smad-dependent BMP signaling. Knockdown impairs cell viability by inhibiting Hippo and JNK signal transduction pathways (in cancer models). Regulation of AP-1/c-Jun, PI3K/Akt pathway, and protein degradation via proteasome.