PMS1 homolog 2, mismatch repair system component pseudogene 5 (PMS2P5)

PMS2P5 is an unprocessed pseudogene homologous to PMS2, a key component of the DNA mismatch repair system. It does not encode a functional protein and has no known enzymatic, signaling, or receptor activity. Pseudogenes like PMS2P5 are commonly found near functional genes such as PMS2 on chromosome 7, and while sometimes involved in gene regulation or recombination events, PMS2P5 itself lacks therapeutic relevance[1][2][4]. There is no evidence for a role in disease or cellular pathways, nor is it considered a valid target for drugs. Its high sequence similarity to PMS2 can complicate genetic analyses, as it may lead to incorrect assignment of mutations during genetic testing for disorders such as Lynch syndrome[3][5].

Other names

PMS2P5PMS2L5PMS4PMS7MGC34222Postmeiotic segregation increased protein 4Postmeiotic segregation increased protein 7Putative postmeiotic segregation increased 2 pseudogene 5