PMS1 homolog 2, mismatch repair system component pseudogene 9 (PMS2P9)

PMS2P9 (PMS1 homolog 2, mismatch repair system component pseudogene 9) is classified as a pseudogene, specifically a non-functional homolog of DNA mismatch repair genes located on human chromosome 7[3]. It shares sequence similarity with functional PMS2 family genes but does not code for a functional protein. While the active PMS2 gene plays a role in DNA repair, pseudogenes like PMS2P9 result from duplication or retrotransposition events and are generally not expressed as proteins and have no established biological or disease-related role[3]. This gene is not considered a therapeutic target, nor is it implicated in drug interaction, biomarker use, or safety concerns. PMS2P9 is sometimes referred to by alternative names including PMS2L17, PMS2LP1, and PMSR5[3]. The existence of PMS2 family pseudogenes can complicate genetic analysis, especially when distinguishing pathogenic variants in the actual PMS2 gene, but PMS2P9 itself does not encode an active biological molecule[2][3].

Other names

PMS2L17PMS2LP1PMSR5