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Target intelligence / Profile preview
Poliovirus Capsid Proteins (Inactivated Virus) (N/A)
- Target
- N/A
- Molecular classification
- Viral structural protein, Capsid protein
01
Overview
Poliovirus capsid proteins are the structural components of the poliovirus outer shell. In inactivated polio vaccines (IPV), these proteins are derived from chemically inactivated poliovirions, rendering them non-infectious but preserving their antigenic properties. The capsid comprises VP1, VP2, VP3, and VP4, arranged in an icosahedral structure. These proteins elicit a protective immune response by presenting conformational epitopes, particularly D-antigen epitopes, without causing disease. The capsid's integrity is crucial for maintaining immunogenicity, and its interaction with the CD155 receptor is important for cell entry during natural infection, though this interaction does not occur with inactivated virus. The three serotypes (PV-1, PV-2, PV-3) are all used to prepare IPV.
- Other names
- VP1VP2VP3VP4Poliovirus structural proteinsPoliovirus D-antigen
02
Mechanism of action
Presentation of viral antigens to stimulate antibody production and cell-mediated immunity.
03
Biological functions
Viral capsid formationAntigen presentationEliciting immune responseReceptor binding (CD155/PVR)
04
Disease associations
PoliomyelitisVaccine development
05
Safety considerations
Maintaining conformational integrity during inactivation and formulation to ensure immunogenicityPotential for incomplete inactivation leading to vaccine-derived poliovirus (VDPV), though extremely rare with IPV
06
Interacting drugs
Formalin (inactivation agent)
1 more in the full profile.
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