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Target intelligence / Profile preview
Poliovirus Type 1 Capsid Protein Antigen (Mahoney Strain)
- Molecular classification
- Viral protein, Capsid protein, Antigen
01
Overview
The poliovirus type 1 capsid protein antigen, specifically from the Mahoney strain, is a structural protein component of the poliovirus serotype 1. The Mahoney strain is a wild-type reference strain widely used in research and vaccine development. The viral capsid comprises four proteins: VP1, VP2, VP3, and VP4. Among these, VP1 is the major surface-exposed protein and plays a critical role in receptor binding and immune recognition. In inactivated polio vaccines, formalin-inactivated Mahoney strain virions containing intact capsids are used for immunization.
- Other names
- Poliovirus type 1 VP1 (Mahoney)Mahoney strain capsid proteinPoliovirus 1 capsid antigen
02
Mechanism of action
Neutralizing antibodies bind to the capsid protein, preventing viral entry into host cells. Inactivated vaccines stimulate the production of these antibodies.
03
Biological functions
Structural component of virionCell entryReceptor binding (CD155/PVR)Elicits immune responseNeutralization by antibodies
04
Disease associations
PoliomyelitisViral infection
05
Interacting drugs
Neutralizing antibodies
1 more in the full profile.
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