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Poliovirus Type 2 Capsid Protein (MEF-1 Strain) (N/A)
- Target
- N/A
- Molecular classification
- Viral structural protein, Capsid protein
01
Overview
The poliovirus type 2 capsid protein from the MEF-1 strain is a structural protein complex forming the outer shell (capsid) of poliovirus serotype 2, specifically the MEF-1 laboratory reference strain. The capsid encapsulates and protects the viral RNA genome and is critical for virus infectivity, antigenicity, and host cell receptor recognition. It is used in both inactivated and oral polio vaccines, and is a model for virus-like particle (VLP) vaccine development.
- Other names
- Poliovirus type 2 capsid proteinPV2 Capsid ProteinMEF-1 Capsid ProteinVP1VP2VP3VP4
02
Mechanism of action
N/A
03
Biological functions
Viral RNA encapsulationHost cell receptor bindingViral entryAntigen presentationImmune response induction
04
Disease associations
PoliomyelitisInfection
05
Safety considerations
Potential for reversion to virulence (OPV)Risk of paralytic poliomyelitis (OPV)Laboratory containment breachAccidental release of lab-derived viruses
06
Interacting drugs
Formalin (inactivated polio vaccine)
1 more in the full profile.
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