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Target intelligence / Profile preview
Poliovirus Type 2 Capsid Protein (Sabin Strain) (N/A)
- Target
- N/A
- Molecular classification
- Viral structural protein, Capsid protein
01
Overview
The poliovirus type 2 capsid protein from the Sabin strain forms part of an attenuated virus used globally as an oral polio vaccine component. Its structure provides both immunogenicity—eliciting strong protective antibody responses—and safety through engineered genetic changes that reduce its ability to cause disease. However, under certain conditions such as low vaccination coverage or prolonged circulation/recombination events within populations or individuals with immune deficiencies, these viruses can mutate back toward more virulent forms capable of causing disease outbreaks similar to wild-type virus infections.
- Other names
- Poliovirus 2 VP1Poliovirus 2 VP2Poliovirus 2 VP3Poliovirus 2 VP4Sabin Poliovirus Type 2 Capsid
02
Mechanism of action
N/A
03
Biological functions
Viral genome protectionCell entryAntigen presentationInduction of neutralizing antibodies
04
Disease associations
PoliomyelitisVaccine-associated paralytic poliomyelitis (VAPP)Vaccine-derived poliovirus (VDPV) outbreaks
05
Safety considerations
Reversion to virulenceVaccine-associated paralytic poliomyelitis (VAPP)Emergence of vaccine-derived polioviruses (VDPVs)
06
Interacting drugs
Neutralizing antibodies
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