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Target intelligence / Profile preview
Poliovirus Type 3 Capsid Protein (Sabin Strain)
- Molecular classification
- Viral protein, Structural protein, Capsid protein
01
Overview
The poliovirus type 3 capsid protein from the Sabin strain forms part of an attenuated live-virus vaccine that safely induces immunity against polio through robust antibody responses targeting its structural components while carrying a low risk profile when administered appropriately. Its structure-function relationship underpins both its effectiveness as a vaccine antigen and rare risks associated with genetic reversion during human replication cycles.
- Other names
- Poliovirus 3 Capsid ProteinSabin Strain Capsid ProteinVP1VP2VP3VP4P1 polyprotein
02
Mechanism of action
Antibody neutralization of viral infectivity
03
Biological functions
Viral genome protectionHost cell attachmentHost cell entryImmune response induction
04
Disease associations
PoliomyelitisVaccine-associated paralytic poliomyelitis (VAPP)
05
Safety considerations
Genetic reversion to neurovirulenceVaccine-associated paralytic poliomyelitis (VAPP)
06
Interacting drugs
None (targeted by vaccine-induced antibodies)
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