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Poly(A) polymerase beta (PAPOLB)
- Target
- PAPOLB
- Molecular classification
- Enzyme, Transferase (poly(A) RNA polymerase)
01
Overview
Poly(A) polymerase beta (PAPOLB) is an mRNA-specific polyadenylate polymerase predominantly expressed in testis that facilitates polyadenylation of mRNA precursors during late spermatogenesis[3]. It adds poly(A) tails to the 3'-ends of pre-mRNAs, regulating mRNA stability and translation. It is encoded by the PAPOLB gene in humans (HGNC: 15970, NCBI Gene: 56903), is localized mainly to the nucleus and endoplasmic reticulum, and has paralogs including the more ubiquitously expressed PAPOLA[3].
- Other names
- PAPTPAP-betaPolynucleotide adenylyltransferase betaTestis-specific poly(A) polymeraseTPAPpoly(A) polymerase beta (testis specific)polynucleotide adenylyltransferase betatestis-specific poly(A) polymerase
02
Biological functions
mRNA processingRNA 3'-end processingspermatogenesis
03
Disease associations
Oculopharyngeal muscular dystrophy 1Stuttering (associations noted, but not an established therapeutic target)
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