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Poly(A) Polymerase Non-canonical PAPD5 (PAPD5)
- Target
- PAPD5
- Molecular classification
- Enzyme, Poly(A) Polymerase, Nucleotidyltransferase
01
Overview
Poly(A) polymerase non-canonical PAPD5 (PAPD5), also known as TENT4A or TRF4-2, is an enzyme involved in RNA surveillance and quality control. It catalyzes the addition of short oligo(A) or oligo(U) tails to RNA substrates, marking them for degradation by the exosome. It plays a role in histone mRNA turnover and regulates telomerase RNA component (TERC) stability. PAPD5 is a therapeutic target in diseases like dyskeratosis congenita and viral infections, with inhibitors showing promise in restoring TERC levels and reducing viral loads.
- Other names
- TENT4ATRF4-2Poly(A) polymerase-associated domain-containing protein 5
02
Mechanism of action
Inhibition of PAPD5/7 activity, leading to increased TERC levels and improved telomerase function; impaired viral RNA tailing activity, leading to destabilization.
03
Biological functions
Post-transcriptional quality controlRNA surveillanceHistone mRNA turnoverTelomerase regulationRNA processing
04
Disease associations
Dyskeratosis congenitaTelomere biology disordersViral Infection
05
Safety considerations
Potential off-target effects of PAPD5/7 inhibitors.
06
Interacting drugs
RG7834
07
Biomarkers
TERC levels
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