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Poly(A) polymerase PAPD5
- Molecular classification
- Enzyme, Noncanonical polyadenylate polymerase
01
Overview
Poly(A)-polymerase-associated domain-containing protein 5 (PAPD5/TENT4B) is a noncanonical poly(A) polymerase involved in post-transcriptional quality control. It adds adenosine residues to the 3' ends of defective RNAs, marking them for exosome-mediated degradation. It plays a key role in regulating ribosomal, histone, and telomeric transcripts and is an emerging drug target for telomere biology disorders such as dyskeratosis congenita.
- Other names
- TENT4BPoly(A) Polymerase-associated Domain-containing Protein 5Noncanonical poly(A) polymerase 5
02
Mechanism of action
Inhibition of PAPD5 activity to prevent excessive oligoadenylation of target RNAs, thus preventing their degradation.
03
Biological functions
RNA quality controlmRNA degradationPolyadenylationRegulation of telomerase RNA component (TERC) stability
04
Disease associations
Dyskeratosis congenita (DC)Telomere biology disorders
05
Safety considerations
Potential off-target effects of PAPD5 inhibitorsLong-term consequences of altered RNA metabolism
06
Interacting drugs
RG7834
1 more in the full profile.
07
Biomarkers
TERC/hTR levelsTelomere length
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