Target intelligence / Profile preview

Poly(A) RNA polymerase D7 (None)

Target
None
Molecular classification
Enzyme, Poly(A) Polymerase
01

Overview

PAPD7 (Poly(A) RNA polymerase D7) is a noncanonical poly(A) polymerase involved in RNA maturation, stability, and degradation. It adds adenine residues to the 3' ends of RNA molecules independently of specific sequence signals. It plays a role in RNA quality control and viral RNA stabilization, particularly in hepatitis B virus (HBV) infection, making it a potential target for antiviral drug development.

Other names
PAPD7Non-canonical Poly(A) Polymerase
02

Mechanism of action

Inhibition of noncanonical poly(A) polymerase activity, leading to destabilization of target RNAs.

03

Biological functions

RNA Quality ControlRNA StabilizationRNA Adenylation
04

Disease associations

InfectionHepatitis B
05

Interacting drugs

AB-452

2 more in the full profile.

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