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Target intelligence / Profile preview
Poly(ADP-ribose) Glycohydrolase (PARG)
- Target
- PARG
- Molecular classification
- Enzyme, Glycohydrolase
01
Overview
Poly(ADP-ribose) glycohydrolase (PARG) is the primary enzyme responsible for the degradation of poly(ADP-ribose) (PAR), a biopolymer synthesized by poly(ADP-ribose) polymerases (PARPs). PARG hydrolyzes the ribose–ribose bonds in PAR, reversing the modifications made by PARPs and thereby regulating cellular processes that depend on dynamic ADP-ribosylation. It plays roles in DNA repair, chromatin dynamics, transcriptional regulation, and cell death.
- Other names
- poly [adenosine diphosphate]-ribose glycohydrolaseEC 3.2.1.143
02
Mechanism of action
Hydrolysis of ribose-ribose bonds in poly(ADP-ribose)
03
Biological functions
DNA repairChromatin remodelingTranscription regulationApoptosisCell cycleMitochondrial functionInflammation response
04
Disease associations
CancerIschemia/Reperfusion InjuryStrokePancreatic Ductal Adenocarcinoma
05
Safety considerations
Lack of optimal selective inhibitors for clinical useBiological role remains less understood than that of PAR synthesis
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