Poly(ADP-ribose) polymerase 10 (PARP10)

Poly(ADP-ribose) polymerase 10 (PARP10) is an enzyme encoded by the PARP10 gene and is part of the PARP family, which is involved in transferring ADP-ribose units from NAD+ to target proteins (mono-ADP-ribosylation). PARP10 is classified as a mono-ADP-ribosyltransferase (mono-ART) and plays a role in the DNA damage response by interacting with proliferating cell nuclear antigen (PCNA) to facilitate translesion DNA synthesis and maintain genomic stability. Loss of PARP10 results in increased genomic instability and hypersensitivity to DNA-damaging agents, while overexpression can either promote apoptosis or cell proliferation depending on cell context. PARP10 suppresses NF-κB signaling and can inhibit the replication of certain single-stranded RNA viruses. It is under investigation as a therapeutic target in cancer and virus-associated diseases, and its activity modulates key cellular processes such as the cell cycle, apoptosis, and DNA repair. Structural studies have characterized its interactions with various inhibitors, providing tools for therapeutic research.

Other names

ARTD10Poly [ADP-ribose] polymerase 10

Inhibition of ADP-ribosyltransferase activity, leading to compromised DNA repair and increased sensitivity to DNA-damaging agents