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Poly(ADP-ribose) Polymerase 14 (PARP14)
- Target
- PARP14
- Molecular classification
- Enzyme, ADP-ribosyltransferase, PARP family member
01
Overview
Poly(ADP-ribose) polymerase 14 (PARP14) is a member of the PARP family of enzymes, primarily catalyzing mono-ADP-ribosylation. It contains RNA recognition motifs, macro domains, a WWE domain, and a catalytic domain. PARP14 participates in DNA damage response, transcriptional regulation (STAT6), immune modulation (Th2 responses), and metabolic reprogramming (Warburg effect). It is implicated in cancer progression/metabolism/resistance and allergic inflammation, making it a potential therapeutic target.
- Other names
- ARTD8BAL2COAST6
02
Mechanism of action
Mono-ADP-ribosylation inhibition
03
Biological functions
DNA damage responseTranscriptional regulationImmune modulationMetabolic reprogrammingCell survival
04
Disease associations
CancerInflammationAllergic inflammationAtherosclerosis
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