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Target intelligence / Profile preview
Poly(ADP-ribose) Polymerase 3 (PARP3)
- Target
- PARP3
- Molecular classification
- Enzyme, Mono ADPr-transferase, Poly(ADPr)-ribose polymerase
01
Overview
Poly(ADP-ribose) polymerase 3 (PARP3) is an enzyme involved in DNA repair, genomic stability, and mitotic progression. It functions primarily as a mono-ADP-ribosyltransferase, modifying target proteins to facilitate DNA repair processes like BER/SSBR and NHEJ. PARP3 also plays a role in stabilizing the mitotic spindle and maintaining telomere integrity. Dysregulation of PARP3 can contribute to genomic instability and cancer development, making it a potential target for cancer therapy.
- Other names
- Poly(ADPr)-ribose polymerase 3
02
Mechanism of action
Inhibition of mono-ADP-ribosylation and/or poly-ADP-ribosylation activity, leading to impaired DNA repair and cell death in cancer cells.
03
Biological functions
DNA damage responseBase excision repair (BER/SSBR)Non-homologous end joining (NHEJ)Mitosis/spindle stabilizationTelomere maintenanceTranscriptional regulationChromatin remodelingInnate immune responseAntiviral defense mechanismsInflammatory regulation
04
Disease associations
CancerGenomic instability
05
Safety considerations
Potential for off-target effects due to PARP family similarities.Development of resistance to PARP inhibitors.
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