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Poly(ADP-ribose) Polymerase 5b (PARP5b)

Target: PARP5b
Molecular classification: Enzyme, Poly(ADP-ribose) polymerase

Overview

Poly(ADP-ribose) polymerase 5b (PARP5b), also known as tankyrase 2 (TNKS2), is an enzyme that catalyzes the transfer of ADP-ribose units to target proteins, a post-translational modification called ADP-ribosylation. TNKS2 is involved in Wnt signaling, telomere maintenance, vesicle trafficking, and DNA damage response, making it a potential therapeutic target, particularly in cancer.

Other names: Tankyrase 2TNKS2ARTD6TANK2

Mechanism of action

Inhibition of PARP5b/TNKS2 enzymatic activity, preventing ADP-ribosylation of target proteins.

Biological functions

Wnt signaling activationTelomere maintenanceVesicle traffickingDNA damage responseDNA repairRegulation of glucose metabolismCell cycle progressionProteasome activity stimulationModulation of innate antiviral responses

Disease associations

Cancer

Safety considerations

Potential for off-target effects due to similarity with other PARP family members.Functional redundancy with TNKS1 may limit efficacy of single-target inhibitors.Embryonic lethality observed in double knockout mice (TNKS1/TNKS2) suggests potential developmental toxicity.

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