Poly (ADP-Ribose) Polymerase 1 (PARP1)

Poly (ADP-ribose) polymerase 1 (PARP1) is a multifunctional nuclear enzyme that plays a central role in DNA repair, chromatin remodeling, transcription regulation, cell cycle control, and programmed cell death. It uses NAD+ to catalyze the transfer of ADP-ribose units onto itself and other target proteins (PARylation). PARP1 acts as a first responder to DNA single-strand breaks (SSBs), binding rapidly to damaged sites and recruiting various DNA repair factors. It is a key target in cancer therapy, particularly in tumors deficient in homologous recombination repair genes like BRCA, where PARP inhibition leads to synthetic lethality.

Other names

ADPRT1

Inhibition of PARP1 enzymatic activity, leading to synthetic lethality in cells deficient in homologous recombination repair (e.g., BRCA-mutated cancer cells).