Poly [ADP-ribose] polymerase 12 (PARP12)

Poly [ADP-ribose] polymerase 12 (PARP12) is an interferon-stimulated, mono-ADP-ribosyltransferase enzyme, primarily located in the cytoplasm, notably at the Golgi apparatus, and can translocate to stress granules upon cellular stress. PARP12 plays key roles in antiviral defense by inhibiting viral mRNA translation, regulating inflammation via NF-κB signaling, and controlling intracellular trafficking. In cancer biology, PARP12 has been linked to chemoresistance, particularly in breast cancer, via regulation of the AKT survival pathway and protein translation. Its catalytic activity (mono-ADP-ribosylation) is crucial for many of these cellular effects. As a therapeutic target, it is less well characterized than PARP1/2 but has emerging roles in immunity and oncogenesis.

Other names

PARP12poly(ADP-ribose) polymerase 12mono-ADP-ribosyltransferase PARP12

Mono-ADP-ribosylation of target proteins (e.g., AKT) to regulate their function; Inhibition of protein translation by associating with the translational machinery; Regulation of intracellular trafficking through stress-induced Golgi fragmentation