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Target intelligence / Profile preview
PorA (Class 1 Outer Membrane Protein) (PorA)
- Target
- PorA
- Molecular classification
- Outer Membrane Protein, Pore-forming protein, Porin
01
Overview
PorA is a major porin protein expressed by most Neisseria meningitidis isolates. It is encoded by the porA gene and contains eight surface-exposed loops with variable regions recognized by subtype-specific antibodies. PorA induces protective bactericidal antibodies and is a major component of outer membrane vesicle (OMV)-based vaccines.
- Other names
- Class 1 Outer Membrane ProteinPorin A
02
Mechanism of action
Antibody binding to variable regions, leading to complement activation and bacterial lysis.
03
Biological functions
Nutrient uptakeSelective diffusionInduction of bactericidal antibodiesImmune response
04
Disease associations
InfectionMeningitisSepticemia
05
Safety considerations
Antigenic variability impacting vaccine effectivenessStrain-specific immunity
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