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Target intelligence / Profile preview
Porphyromonas gingivalis (bacterium) (P. gingivalis)
- Target
- P. gingivalis
- Molecular classification
- Other (strictly, this is a bacterial species, not a molecular classification such as enzyme, receptor, transporter, etc.)
01
Overview
Porphyromonas gingivalis is a **Gram-negative, anaerobic, nonmotile, rod-shaped bacterium** that is a major pathogen in the oral cavity, especially associated with periodontal disease.[1][3][5] Its pathogenicity is due to a variety of virulence factors, including proteases (especially gingipains), fimbriae, lipopolysaccharides (LPS), capsule, and the ability to modulate and evade the host immune response.[1][5][6][7] The bacterium thrives in subgingival biofilms, degrading host tissue and manipulating inflammatory signaling, and is also associated with systemic diseases such as rheumatoid arthritis and Alzheimer’s disease.[1][3]
- Other names
- Bacteroides gingivalisformerly Bacteroides melaninogenicus
02
Mechanism of action
Not applicable (since this entry is a whole bacterium, not a druggable molecular target)
03
Biological functions
Pathogenic microorganismBiofilm formationHost cell invasionExtracellular matrix degradationEvasion of host immune response
04
Disease associations
InfectionPeriodontitis (chronic and aggressive forms)Associated with rheumatoid arthritis, Alzheimer’s disease, and other systemic conditions
05
Safety considerations
Antibiotic resistancePathogenicity and involvement in chronic inflammationSystemic dissemination in immunocompromised individuals
06
Interacting drugs
Antibiotics (general, no single drug universally used or specific direct interaction with a “target” molecule)
07
Biomarkers
Presence of anti-P. gingivalis antibodiesdetection of P. gingivalis DNA in clinical materialanti-HmuY antibodies in periodontitis patients
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