Potassium channel AKT1 (Musa acuminata) (MaAKT1)

MaAKT1 is a Shaker-like inward-rectifying potassium channel primarily expressed in the roots of the banana plant (Musa acuminata) (UniProt A0A804K9Z7). It serves as the dominant pathway for potassium (K+) acquisition from the soil across a wide range of environmental concentrations, making it vital for plant growth, development, and osmotic regulation (Zhang et al., 2025). MaAKT1 has recently been identified as a critical target in the pathogenesis of Fusarium wilt (Panama disease), where the fungal phytotoxin fusaric acid induces S-glutathionylation of the channel at the conserved Cys202 residue (PLOS Pathogens, 2025). This modification inhibits K+ uptake, leading to systemic potassium deficiency and the characteristic symptoms of the disease, such as leaf yellowing and necrosis. Consequently, MaAKT1 is a significant target for agricultural biotechnology aimed at developing disease-resistant banana cultivars and improving crop resilience to abiotic stresses like salinity. Research into MaAKT1 modulators, such as inorganic blockers like cesium and barium or protective antioxidants, provides a foundation for future strategies to treat Fusarium wilt and increase banana production (Zhang et al., 2025).

Other names

Banana AKT1Musa acuminata AKT1Shaker-like inward-rectifier potassium channel AKT1

Inhibition of potassium influx through S-glutathionylation of the Cys202 residue or direct pore blockade (Zhang et al., 2025).