Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Potassium channel protein (transient outward current) (Ito1)
- Target
- Ito1
- Molecular classification
- Ion channel, Potassium channel, Voltage-gated potassium channel
01
Overview
The potassium channel protein responsible for the transient outward current, commonly referred to as Ito or specifically Ito1 in cardiac tissue, is a voltage-gated potassium channel that plays a critical role in the early phase of repolarization during the cardiac action potential. This current is characterized by its rapid activation and subsequent quick inactivation following membrane depolarization. It contributes significantly to phase 1 of the cardiac action potential, producing a brief repolarizing "notch" before the plateau phase. Alterations or dysfunctions in Ito are implicated in arrhythmias and other cardiac pathologies due to their effect on action potential duration and morphology.
- Other names
- Cardiac transient outward K+Transient outward potassium currentItoKv4.2/Kv4.3 channelKv1.4 channel
02
Mechanism of action
Blockage of the fast component (Ito,f/Kv4.x-based) of the transient outward potassium current.
03
Biological functions
Regulation of cardiac action potential durationEarly repolarization of cardiac myocytesModulation of calcium entry during phase 2 of action potentialRegulation of excitation-contraction coupling
04
Disease associations
Arrhythmogenic syndromesHeart failureCardiovascular disease
05
Safety considerations
Altered expression or function can lead to arrhythmiasReduced Ito can prolong action potentials and predispose to arrhythmias
06
Interacting drugs
4-Aminopyridine (4-AP)
Beyond the preview
Go deeper on Potassium channel protein (transient outward current) (Ito1).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Potassium channel protein (transient outward current) (Ito1).