PPARGC1 and ESRR-induced regulator, muscle 1 (PERM1) (PERM1)

PPARGC1 and ESRR-induced regulator, muscle 1 (PERM1) is a muscle-specific protein that serves as a vital regulator of mitochondrial biogenesis and oxidative metabolism (UniProt Q5T0U0). It is transcriptionally induced by the coactivator PGC-1α and the nuclear receptor ERR, and it further acts to enhance their transcriptional activity in a feed-forward loop (Cho et al., 2013, PubMed). This regulation is crucial for maintaining the expression of genes involved in the tricarboxylic acid cycle, fatty acid oxidation, and the electron transport chain (NCBI Gene ID: 84808). Research indicates that PERM1 levels are significantly reduced in models of heart failure and skeletal muscle wasting, highlighting its importance in maintaining cardiac and muscular energy homeostasis (Cho et al., 2019, PubMed). Consequently, PERM1 is considered a potential therapeutic target for metabolic and cardiovascular diseases where mitochondrial dysfunction is a primary driver. Although no direct pharmacological modulators of PERM1 are currently available, its central role in energy metabolism makes it a focus for future drug discovery and gene therapy approaches.

Other names

C1orf170PGC-1 and ERR-induced regulator in muscle protein 1Chromosome 1 open reading frame 170

Transcriptional co-activation of PGC-1α and ERRα/γ pathways to promote mitochondrial gene expression (Cho et al., 2013, PubMed).