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Target intelligence / Profile preview
Premature Termination Codon (TAG) (PTC (TAG))
- Target
- PTC (TAG)
- Molecular classification
- Genetic Code, RNA sequence, Stop codon
01
Overview
A premature termination codon (PTC), specifically the TAG codon, is a stop codon that appears within the coding sequence of an mRNA earlier than expected, typically due to mutations or aberrant splicing. It signals premature termination of translation, resulting in truncated proteins that are often nonfunctional and can be detrimental. Cells employ mechanisms like NMD to degrade mRNAs containing PTCs.
- Other names
- UAGPremature Stop CodonNonsense MutationTruncated ProteinTAG codon
02
Mechanism of action
N/A
03
Biological functions
Translation TerminationRegulation of Gene ExpressionNonsense-mediated mRNA decay (NMD)
04
Disease associations
Genetic DisordersCancerInherited Diseases
05
Safety considerations
Production of non-functional or harmful truncated proteins
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