Primary microRNA-17~92 cluster transcript (pri-miR-17~92) (pri-miR-17~92)

The primary microRNA-17~92 cluster transcript (pri-miR-17~92) is a polycistronic non-coding RNA encoded by the MIR17HG gene on chromosome 13 (He et al., 2005, Nature 435:828-833). It serves as the precursor for six mature microRNAs: miR-17, miR-18a, miR-19a, miR-20a, miR-19b-1, and miR-92a-1, which are critical regulators of gene expression (Mogilyansky & Rigoutsos, 2013, Cell Death Differ. 20(12):1603-14). This cluster, often termed "Oncomir-1," is frequently amplified or overexpressed in a wide range of cancers, including B-cell lymphomas and lung cancer, where it drives oncogenesis by promoting cell cycle progression and inhibiting apoptosis (Concepcion et al., 2012, FEBS J. 279(2):202-10). In normal physiology, the transcript is essential for proper development of the heart, lungs, and immune system (Velu & Grimes, 2012, Genes Cancer 3(11-12):602-9). Therapeutic strategies targeting pri-miR-17~92 include antisense oligonucleotides and small molecules that bind to specific secondary structures within the transcript to block its processing by the Drosha-DGCR8 complex (Disney et al., 2016, ACS Chem. Biol. 11(6):1720-8). While targeting this cluster holds significant potential for treating overexpressing tumors, challenges include achieving tissue specificity and avoiding the disruption of its essential roles in normal cellular homeostasis.

Other names

MIR17HGOncomir-1C13orf25miR-17-92 clusterPrimary microRNA-17-92

Inhibition of Drosha-mediated processing, antisense-mediated sequestration, and RNA interference-mediated degradation of the primary transcript.