Prochemerin (precursor of chemerin)

Prochemerin is the inactive, secreted precursor of chemerin, a protein produced by the *RARRES2* gene. It consists of 143 amino acids and requires proteolytic cleavage at the C-terminus by various proteases from the coagulation, fibrinolytic or inflammatory cascades to generate biologically active chemerin. Only the activated chemerin binds to and acts via its G protein-coupled receptors—especially CMKLR1 (ChemR23)—to mediate immune cell chemotaxis, adipocyte differentiation, metabolic regulation, and inflammatory signaling. Prochemerin does not bind chemerin receptors or directly mediate these biologic actions, but is the essential source protein for generating various chemerin isoforms with distinct activities[5][7][3]. Summary: "Prochemerin" is best described as an inactive precursor and not a therapeutically actionable target, receptor, or enzyme. All major biological, disease, and pharmacological roles are attributed to its processed product, chemerin, and especially to chemerin's interaction with GPCRs (e.g., CMKLR1/ChemR23). If your use case is therapeutic targeting, data capture, or biomarker study, you likely want to focus on "chemerin" or its receptors, not "prochemerin"[5][7][3][4].

Other names

Pro-chemerinprochemerinchemoattractant protein precursor