Programmed cell death protein 1 (canine) (PD-1)

Programmed cell death protein 1 (PD-1) is a type I transmembrane receptor expressed on the surface of T cells and other immune cells in dogs. It acts as an immune checkpoint, suppressing T cell activity by binding to its ligands, PD-L1 and PD-L2, which can be exploited by tumors and pathogens to evade immune attack. Canine PD-1 is structurally and functionally homologous to human PD-1 and is a validated target for immunotherapy in comparative oncology. Monoclonal antibodies and nanobodies have been developed to block the interaction between canine PD-1 and its ligands, showing promise in restoring antitumor immunity in canine cancer models. PD-1 remains an important target in both veterinary therapeutics and diagnostic applications, with ongoing research into its efficacy and safety profile in dogs[1][3][4][5].

Other names

PD-1programmed death-1PDCD1

Immune checkpoint inhibition (blocking PD-1/PD-L1 or PD-1/PD-L2 interaction to reactivate T cells)