Proline rich 5, renal–Rho GTPase activating protein 8 readthrough (PRR5-ARHGAP8)

Proline rich 5, renal–Rho GTPase activating protein 8 readthrough (PRR5-ARHGAP8) is a naturally occurring human fusion transcript formed by transcriptional read-through between the neighboring PRR5 and ARHGAP8 genes[4][1]. The resulting fusion protein contains sequence elements from both parental gene products, including domains typical of RhoGAP proteins. The biological function of PRR5-ARHGAP8 itself has not been determined experimentally; however, PRR5 is a subunit of the mTORC2 kinase complex involved in neuronal survival, energy regulation, and proliferation, while ARHGAP8 is a GAP family protein regulating cytoskeletal dynamics and Rho GTPase signaling[1][2][4]. Expression of this fusion protein occurs at low levels and appears tissue-specific. Genome-wide association studies suggest a possible link to binge eating behavior in the context of bipolar disorder, but no direct therapeutic, biomarker, or disease-modifying roles have been confirmed for the fusion at present[1][4].

Other names

PRR5-ARHGAP8 fusion proteinPRR5-ARHGAP8 fusionPRR5-ARHGAP8B1AHC3 Protein

None established for direct targeted inhibition or activation—mechanism unknown.