Prostaglandin F receptor (FP) (PTGFR)

The Prostaglandin F receptor (FP), encoded by the PTGFR gene, is a G protein-coupled receptor (GPCR) that selectively binds prostaglandin F2-alpha (PGF2alpha) (UniProt KB: P43088). It primarily signals through the Gq/11 protein family, triggering phospholipase C activation and subsequent increases in intracellular calcium (IUPHAR/BPS Guide to Pharmacology). This receptor is highly expressed in the ciliary body of the eye and the myometrium of the uterus, where it regulates aqueous humor outflow and smooth muscle contraction, respectively (StatPearls: Prostaglandin Analogs). In ophthalmology, FP receptor agonists like latanoprost are the gold standard for treating glaucoma by enhancing uveoscleral drainage to lower intraocular pressure (PubMed: PMID 25394795). In obstetrics, the receptor is targeted by drugs like dinoprost to induce labor or control postpartum hemorrhage by stimulating uterine contractions (NCBI Gene: 5737). Beyond these applications, the FP receptor is involved in inflammatory pathways and has been linked to the progression of certain cancers and endometriosis (PubMed: PMID 28651654).

Other names

FP receptorProstanoid FP receptorPGF receptorProstaglandin F2-alpha receptor

Agonism of the FP receptor activates the Gq/11 signaling pathway, leading to increased intracellular calcium and activation of protein kinase C. In the eye, this increases uveoscleral outflow to reduce intraocular pressure. In the uterus, it induces myometrial contractions.