Prostaglandin F receptor (PTGFR) (PTGFR)

The Prostaglandin F receptor (PTGFR), also known as the FP receptor, is a G protein-coupled receptor (GPCR) that mediates the physiological actions of prostaglandin F2-alpha (PGF2α) (UniProt: P43088). It is primarily coupled to the Gq signaling pathway, which triggers phospholipase C activation and increases intracellular calcium (PubMed: 10428871). In ophthalmology, PTGFR is a major therapeutic target because its activation in the ciliary muscle and trabecular meshwork enhances the uveoscleral outflow of aqueous humor (StatPearls: NBK539777). This mechanism is utilized by prostaglandin analogs like latanoprost acid, the active form of the prodrug latanoprost, to reduce intraocular pressure in patients with open-angle glaucoma or ocular hypertension (PubChem CID: 5311001). Beyond ocular tissues, PTGFR is expressed in the female reproductive system, where it regulates luteolysis and uterine contractions during labor (NCBI Gene: 5737). Therapeutic modulation of this receptor is highly effective but can lead to side effects such as increased iris pigmentation and eyelash growth (PubMed: 11417671).

Other names

FP receptorProstanoid FP receptorPGF receptorProstaglandin F2-alpha receptorPTGFR

Agonism of the Prostaglandin F receptor increases the uveoscleral outflow of aqueous humor, thereby reducing intraocular pressure (StatPearls: NBK539777).