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Target intelligence / Profile preview
Prostate cancer associated transcript 18 (non-protein coding) (PCAT18)
- Target
- PCAT18
- Molecular classification
- Long intergenic noncoding RNA (lincRNA), Non-coding RNA
01
Overview
Prostate cancer associated transcript 18 (PCAT18) is a long intergenic non-protein coding RNA (lincRNA), also known as LINC01092, that is highly specific to prostate cancer and regulated by the androgen receptor. As a lincRNA, PCAT18 does not encode a protein but is implicated in the regulation of gene expression, often acting as a molecular sponge for specific microRNAs (such as miR-103a-3p), thereby modulating downstream transcriptional activity. PCAT18 and other lincRNAs participate in diverse cellular processes, including cell cycle regulation, apoptosis, and cell proliferation, and may serve as diagnostic or prognostic biomarkers for cancer. There is evidence for disease association (primarily cancer), but no evidence that PCAT18 is currently a direct therapeutic target or that there are drugs targeting it.
- Other names
- LINC01092long intergenic non-protein coding RNA 1092PCAT18prostate cancer associated transcript 18 (non-protein coding)
02
Biological functions
Regulation of gene expressionRNA processingModulation of cell proliferationModulation of cell death (apoptosis)Interaction with microRNAs (molecular sponge)
03
Disease associations
Cancer (especially prostate cancer, possibly others through dysregulation of lincRNAs)
04
Biomarkers
Potential biomarker for prostate cancer and cancer progression
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