Proteasome 26S subunit, ATPase 1 pseudogene 3 (PSMC1P3)

PSMC1P3 (proteasome 26S subunit, ATPase 1 pseudogene 3) is a pseudogene that resembles the gene encoding an ATPase subunit of the 26S proteasome but does not produce a functional protein, nor is it part of the canonical proteasome complex[1][7]. It is listed as ENSG00000231244 in Ensembl and does not have known biological or disease-associated roles. Functional protein-coding genes from the 26S proteasome ATPase subunit family, such as PSMC1 and PSMC3, participate in ATP-dependent ubiquitin-mediated protein degradation, but PSMC1P3 itself does not encode a receptor, enzyme, transporter, or any other canonical drug target class[1][7]. Essential context and supporting details: - PSMC1P3 is explicitly labeled a "pseudogene" in genomic databases, meaning it is a non-functional remnant of a gene that arose through gene duplication or retrotransposition, and it does not produce an active protein[1][7]. - There is no evidence from genetic, proteomic, or pharmacological resources that PSMC1P3 has any functional role in cellular processes, nor is it targeted by any known therapies[1][7]. - It should not be confused with PSMC1 or other 26S proteasome ATPase subunit genes, which do encode functional proteins involved in protein degradation and cellular homeostasis[8][2][4]. If you intended to refer to a functional proteasome ATPase subunit (such as PSMC1 or PSMC3), those proteins have significant biological and therapeutic relevance but are distinct from PSMC1P3.

Other names

Proteasome (prosome, macropain) 26S subunit, ATPase, 1 pseudogene 3proteasome 26S subunit, ATPase 1 pseudogeneENSG00000231244