Proteasome 26S subunit, ATPase 1 pseudogene 4 (PSMC1P4)

PSMC1P4 is a human pseudogene that corresponds to the proteasome 26S subunit, ATPase 1 (PSMC1) gene[1]. Unlike the protein-coding PSMC1 gene, PSMC1P4 does not produce a functional protein product and is not involved in encoding an active proteasome subunit. Pseudogenes are typically nonfunctional remnants of gene duplication or retrotransposition events. Therefore, PSMC1P4 is not considered a therapeutic target, does not have biological functions, and has no known disease associations, drug interactions, mechanisms of action, known biomarkers, or safety concerns[1]. Key points: - PSMC1P4 is a pseudogene, not an active gene or protein[1]. - It is not a drug target—therapeutic interventions do not act on this pseudogene. - No functional, mechanistic, or biomarker relevance is reported. - The confusion may arise because the active gene, PSMC1, does encode an essential subunit of the 26S proteasome—a validated therapeutic target in cancer and other diseases[2][5][7]. However, PSMC1P4 itself does not have these properties. If you require information on the active subunit/target (PSMC1), a separate entry should be used.

Other names

Proteasome (prosome, macropain) 26S subunit, ATPase, 1 pseudogene 4PSMC1P4