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Target intelligence / Profile preview
Proteasome-Associated Deubiquitinase (19S Regulatory Subunit) (19S RP DUB)
- Target
- 19S RP DUB
- Molecular classification
- Enzyme, Deubiquitinase, Proteasome Subunit
01
Overview
The proteasome-associated deubiquitinases are a group of enzymes located within the 19S regulatory particle (RP) of the 26S proteasome. These DUBs, including Rpn11, USP14, and UCHL5/UCH37, play a crucial role in removing ubiquitin chains from substrates before their degradation, ensuring efficient recycling of ubiquitin molecules. They are essential for maintaining cellular protein homeostasis and are implicated in various diseases, including cancer.
- Other names
- Proteasome 19S Regulatory Particle Deubiquitinase19S RP DUBRpn11PSMD14USP14UCHL5UCH37
02
Mechanism of action
Inhibition of deubiquitinase activity, leading to impaired protein degradation and accumulation of ubiquitinated proteins.
03
Biological functions
Protein degradationUbiquitin recyclingRegulation of protein homeostasisSubstrate deubiquitinationProteasome assembly and function
04
Disease associations
CancerNeurodegenerative diseaseInflammation
05
Safety considerations
Potential for off-target effects due to the broad role of the proteasome in cellular processes.Development of resistance to proteasome inhibitors.Neurotoxicity
06
Interacting drugs
Bortezomib
2 more in the full profile.
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