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Protein Kinase (Isoform-Specific) (N/A)
- Target
- N/A
- Molecular classification
- Enzyme, Protein Kinase, Serine/Threonine Kinase, Tyrosine Kinase
01
Overview
Protein kinases are a large family of enzymes that catalyze the transfer of phosphate groups from ATP to specific amino acids (serine, threonine, or tyrosine) on substrate proteins. Isoform-specific protein kinases refer to distinct variants (isoforms) within a kinase family that arise from different genes or alternative splicing and often have unique regulatory properties, subcellular localizations, and physiological functions. Dysregulation/mutation of specific kinase isoforms contributes to diseases such as cancer/metabolic disorders/neurodegeneration. Development of inhibitors/disruptors that target individual kinase isoforms offers potential therapeutic advantages by minimizing off-target effects seen with pan-inhibitors.
- Other names
- Protein Kinase A (PKA) IsoformsProtein Kinase C (PKC) IsoformsAKT/PKB IsoformsPKAPKCAKTPKB
02
Mechanism of action
Phosphorylation of target proteins, regulation of cellular processes.
03
Biological functions
Signal transductionCell cycleApoptosisMetabolismCell proliferationCell growthSynaptic plasticityGlucose homeostasis
04
Disease associations
CancerMetabolic disordersNeurodegenerationMemory/cognition disordersDiabetes
05
Safety considerations
Off-target effectsToxicity when using pan-inhibitors
06
Interacting drugs
PKA inhibitors
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