Protein kinase C delta (PKCδ) (PKCδ)

Protein kinase C delta (PKCδ) is a member of the novel PKC subfamily of serine/threonine kinases that plays a pivotal role in cellular signaling, particularly in response to oxidative stress and ischemia (UniProt P18056). A critical pathological mechanism involves the translocation of PKCδ from the cytosol to the mitochondria, where it interacts with the kinase regulatory domain of the Pyruvate Dehydrogenase (PDH) complex (Churchill et al., 2008, Nature 452:753-757). This interaction leads to the phosphorylation and inhibition of PDH, which suppresses oxidative phosphorylation (OXPHOS), reduces ATP production, and promotes the generation of reactive oxygen species (ROS) (Murriel et al., 2004, JBC 279:47}

Other names

PRKCDnPKC-deltaProtein kinase C delta typeTyrosine-protein kinase PRKCDMAY1

Selective inhibition of PKCδ translocation to the mitochondria or inhibition of its kinase activity to prevent the phosphorylation and inactivation of the pyruvate dehydrogenase (PDH) complex, thereby maintaining oxidative phosphorylation (OXPHOS) and reducing mitochondrial-driven apoptosis.