Protein phosphatase 1D mRNA 3'-untranslated region (PPM1D mRNA 3'-UTR)

The Protein phosphatase 1D (PPM1D) mRNA 3'-untranslated region (3'-UTR) is a critical regulatory segment of the PPM1D transcript, which encodes the WIP1 phosphatase, a member of the PP2C family (Source: UniProt, P49757). This region serves as a primary site for post-transcriptional control, containing binding motifs for several microRNAs such as miR-16 and miR-145 that negatively regulate PPM1D expression (Source: PubMed, PMID: 21150130, 25605116). PPM1D functions as an oncogene by dephosphorylating and inactivating key proteins in the DNA damage response pathway, including p53, Chk1, and p38 MAPK, thereby promoting cell survival and inhibiting apoptosis (Source: PubMed, PMID: 15184876). Overexpression or gain-of-function mutations in PPM1D are frequently observed in breast, ovarian, and lung cancers, often correlating with poor prognosis (Source: PubMed, PMID: 24403010). Therapeutic targeting of the 3'-UTR using antisense oligonucleotides (ASOs) or microRNA mimics aims to reduce PPM1D protein levels, effectively restoring the cell's ability to undergo p53-mediated cell cycle arrest or apoptosis in response to DNA damage (Source: PubMed, PMID: 28655774). This approach is particularly relevant for sensitizing tumor cells to conventional chemotherapy and radiotherapy.

Other names

WIP1 mRNA 3'-UTRProtein phosphatase magnesium-dependent 1 delta mRNA 3'-UTRPP2C-delta mRNA 3'-UTR

Inhibition of translation and induction of mRNA degradation via RNA interference or antisense binding.