Protein phosphatase 2 regulatory subunit B alpha (PPP2R2A) (PPP2R2A)

Protein phosphatase 2 regulatory subunit B alpha (PPP2R2A), also known as B55alpha, is a critical regulatory component of the Protein Phosphatase 2A (PP2A) holoenzyme, which serves as a major serine/threonine phosphatase in eukaryotic cells [1, 2]. PPP2R2A specifically directs the PP2A catalytic core to substrates involved in cell cycle progression, DNA damage repair, and survival signaling pathways such as AKT and MAPK [2, 4]. In many human cancers, particularly prostate, breast, and colorectal carcinomas, PPP2R2A is frequently downregulated or genomically deleted, functioning as a tumor suppressor whose loss promotes uncontrolled proliferation and genomic instability [3]. While direct therapeutic targeting of the PPP2R2A mRNA or protein remains an area of active research, its absence serves as a significant biomarker for synthetic lethality approaches, such as the use of PARP or WEE1 inhibitors [3]. Current pharmacological efforts include the development of Small Molecule Activators of PP2A (SMAPs) that aim to stabilize the PPP2R2A-PP2A complex and restore its phosphatase activity to suppress tumor growth [4].

Other names

B55AB55-ALPHAPR52APR55AB55alphaPPP2R2A mRNA

Activation of the PP2A-B55alpha complex to restore phosphatase activity; synthetic lethality via PARP or WEE1 inhibition in the context of PPP2R2A deficiency.