Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Protein phosphatase 3 regulatory subunit B, beta (PPP3R2)
- Target
- PPP3R2
- Molecular classification
- Enzyme regulator, Regulatory subunit of serine/threonine phosphatase, Calcineurin complex component
01
Overview
Protein phosphatase 3 regulatory subunit B, beta (PPP3R2) is a regulatory subunit of calcineurin (protein phosphatase 3), a calcium- and calmodulin-dependent serine/threonine protein phosphatase that plays a critical role in signal transduction pathways, especially in T-cell activation and neuronal signaling[8][10]. The beta subunit confers calcium sensitivity to the calcineurin enzyme complex and participates in the regulation of immune response and neurological signaling[8]. The gene encoding this subunit is protein coding, with related roles in pathways such as cAMP-Dependent PKA activation and TCR signaling[8][10].
- Other names
- Calcineurin subunit B type IIProtein phosphatase 3 (formerly 2B), regulatory subunit B (19kD), beta isoform (Calcineurin B, type II)Calcineurin B-like protein (CBLP)PPP3RLPPP3R1-likeProtein phosphatase 3, regulatory subunit B (calcineurin B)-like
02
Mechanism of action
Immunosuppressive drugs (e.g., cyclosporin, tacrolimus) inhibit calcineurin phosphatase activity by binding to immunophilins, which then block the calcineurin complex (including the regulatory subunit B, beta), suppressing T cell activation and immune response
03
Biological functions
Calcium-dependent regulation of protein serine/threonine phosphatase activityCalcineurin-mediated signal transductionModulating calcium signaling pathways
04
Disease associations
Neurodegenerative disease (implicated via calcineurin signaling pathway)Immunological regulation (immune response via calcineurin pathway)Other (fertility: penetration of zona pellucida in reproduction)
05
Safety considerations
Long-term inhibition of calcineurin can result in nephrotoxicity, neurotoxicity, and immunosuppression due to disruption of normal calcium signaling and T-cell regulation
06
Interacting drugs
Cyclosporin A (by inhibition of calcineurin, though it binds to the catalytic subunit, the regulatory subunit B is required for full function)
1 more in the full profile.
07
Biomarkers
No direct clinical use as a biomarker, but altered calcineurin composition (including PP3R2) can affect cellular calcium signaling or be studied in the context of immune and neurodegenerative disorders
Beyond the preview
Go deeper on Protein phosphatase 3 regulatory subunit B, beta (PPP3R2).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Protein phosphatase 3 regulatory subunit B, beta (PPP3R2).