Protein phosphatase 6 catalytic subunit (PPP6C) (PPP6C)

Protein phosphatase 6 catalytic subunit (PPP6C) is a serine/threonine phosphatase that serves as the catalytic component of the protein phosphatase 6 (PP6) holoenzyme [1]. It plays a vital role in cellular processes such as cell cycle progression, particularly the G1/S transition, and the regulation of the DNA damage response by dephosphorylating gamma-H2AX [1, 3]. PPP6C also modulates the NF-kappaB signaling pathway, influencing inflammatory responses and cell survival [1]. In clinical oncology, PPP6C is identified as a frequently mutated gene in cutaneous melanoma, where it typically functions as a tumor suppressor [2]. Its loss or inactivation promotes genomic instability and accelerated tumor growth in various cancer models [2]. While no small molecule drugs are currently approved for this target, PPP6C mRNA is a focus of research for RNA-interference-based therapies designed to modulate its expression in various disease contexts [3]. Therapeutic strategies targeting this molecule must account for its broad regulatory roles to avoid significant off-target toxicity and disruption of essential cellular homeostasis. The mRNA itself is considered a target for antisense oligonucleotides (ASOs) and siRNAs in experimental settings to study its role in oncogenesis and immune signaling [3]. [1] UniProt (O00743) [2] Nature Genetics (2012) 44(10):1108-14 [3] NCBI Gene (5537)

Other names

PP6PP6CProtein phosphatase 6Serine/threonine-protein phosphatase 6 catalytic subunit

Modulation of protein expression through mRNA degradation or translational inhibition using RNA-targeted modalities.