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Proto-oncogene protein c-Met (hepatocyte growth factor receptor) (MET)

Target: MET
Molecular classification: Receptor, Tyrosine Kinase, Receptor Tyrosine Kinase (RTK)

Overview

MET, also known as the hepatocyte growth factor receptor (HGFR), is a receptor tyrosine kinase that plays a crucial role in cell proliferation, motility, morphogenesis, and survival. Upon binding its ligand, hepatocyte growth factor (HGF), MET dimerizes and autophosphorylates, activating downstream signaling pathways including PI3K/AKT, RAS/MAPK, and STAT. Aberrant MET activation, often through overexpression, amplification, or mutation, contributes to tumorigenesis across various cancers, making it an established therapeutic target.

Other names: c-MetHepatocyte Growth Factor ReceptorHGFR

Mechanism of action

Tyrosine kinase inhibition

Biological functions

Cell proliferationScattering/motilityMorphogenesisSurvival/apoptosis escapeSignal transduction

Disease associations

Cancer

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