Proto-oncogene tyrosine-protein kinase Src (c-Src) (c-Src)

Proto-oncogene tyrosine-protein kinase Src (c-Src) is a non-receptor tyrosine kinase that serves as a critical mediator in various signaling pathways governing cell growth, differentiation, adhesion, and migration [1, 6]. As the prototypical member of the Src family kinases (SFKs), it is activated by a wide array of cell surface receptors, including receptor tyrosine kinases (RTKs), G protein-coupled receptors (GPCRs), and integrins [1, 7]. Under normal physiological conditions, c-Src activity is tightly regulated through phosphorylation at specific tyrosine residues; however, its dysregulation or overexpression is a hallmark of numerous malignancies, such as colon, breast, and lung cancers [6, 11]. In these contexts, hyperactive c-Src promotes tumor progression, epithelial-}

Other names

SRCproto-oncogene c-Srcpp60c-srctyrosine-protein kinase SRC-1p60-Srcv-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog

ATP-competitive inhibition of the tyrosine kinase domain, preventing the phosphorylation of downstream substrates and inhibiting signal transduction pathways such as PI3K/Akt and Ras/MAPK [11, 13].