Target intelligence / Profile preview

Protocadherin gamma subfamily A, 3 (PCDHGA3)

Target: PCDHGA3
Molecular classification: Cadherin superfamily, Protocadherin gamma subfamily, Cell adhesion molecule

Overview

Protocadherin gamma subfamily A, 3 is a member of the protocadherin gamma gene cluster, tandemly linked on chromosome 5, and encodes a neural cadherin-like cell adhesion protein. Its structure, with multiple cadherin ectodomains and a transmembrane region, facilitates calcium-dependent cell adhesion vital for the specificity of neural connections in the brain. PCDHGA3 is broadly expressed in the nervous system, is upregulated in follicular lymphoma (serving as a diagnostic marker), and may play broader roles in neurodevelopment and cancer biology, including modulation of cell proliferation[1][2][3][5]. There are no known drugs or safety concerns associated because it has not been established as a therapeutic target.

Other names: Protocadherin gamma-A3PCDHGA3PCDH-gamma-A3PCDH-GAMMA-A3protocadherin γ A3

Mechanism of action

Not applicable, as there are no known drugs targeting PCDHGA3.

Biological functions

Calcium ion bindingCell adhesion (especially neural cell-cell connections)Establishment and maintenance of neuronal networksPotential epigenetic marker of aging

Disease associations

Neurodevelopmental disorders with poor growth and skeletal anomaliesChildhood central nervous system embryonal tumorFollicular lymphoma (diagnostic marker, not as a pathogenic driver)Potential tumor suppression (epigenetic downregulation in various cancers)

Biomarkers

Immunohistochemical marker for follicular lymphoma, including BCL2-negative FL casesMarker for cell proliferation in FL-derived linesEpigenetic marker of aging (potential research use)

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