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Protocadherin gamma subfamily B, 6 (PCDHGB6)
- Target
- PCDHGB6
- Molecular classification
- Cadherin superfamily, Cell adhesion molecule, Plasma membrane protein, Calcium-dependent cell-adhesion protein
01
Overview
Protocadherin gamma subfamily B, 6 (PCDHGB6) is a member of the protocadherin gamma gene cluster located on chromosome 5, encoding a neural cadherin-like cell-adhesion protein that contains six cadherin ectodomains and a transmembrane region, with a cytoplasmic tail shared among gamma cluster members. The protein is likely involved in calcium-dependent homophilic cell adhesion and is thought to play a role in establishing and maintaining specific neuronal connections in the brain. While associated with neurodevelopmental disorders, it is not currently known as a therapeutic target or associated with any drugs[1][2][5][3].
- Other names
- Protocadherin gamma-B6PCDH-gamma-B6PCDH-GAMMA-B6protocadherin gamma-B6
02
Biological functions
Cell adhesionNeuronal connectivityNervous system developmentCalcium ion binding
03
Disease associations
Neurodevelopmental disorder with poor growth and skeletal anomaliesMicrocephaly
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